Elevated Clotting Factor Levels and Venous Thrombosis
نویسندگان
چکیده
منابع مشابه
Elevated clotting factor levels and venous thrombosis.
Increased plasma levels of fibrinogen, factor VIII (FVIII), factor IX (FIX), factor XI (FXI) and prothrombin all were reported to be independent risk factors of venous thromboembolism (VTE). However there is only limited information on the molecular basis of these plasma phenotypes. In addition some of these plasma phenotypes may form clusters, which may point to defects in common pathways affe...
متن کاملRecurrent Cerebral Venous Thrombosis Associated with Elevated Factor VIII
Cerebral venous thrombosis (CVT) rarely recurs, and the factors associated with a recurrence remain unclear. Recently, however, elevated plasma coagulation factor VIII has been considered a factor related to recurrent venous thromboembolism. Here we report a patient who had recurrent CVT associated with significantly elevated levels of factor VIII despite the chronic use of an antiplatelet agen...
متن کاملElevated factor VIII levels and the risk of thrombosis.
In vivo, a delicate balance exists between fibrin formation and fibrinolysis. Reduced blood flow, changes in the vessel wall, and changes in blood composition (hypercoagulability)1 may all result in a disturbance of this balance, which favors fibrin formation and ultimately may lead to the formation of occlusive thrombi. Venous thromboembolism is the result of clot formation in a vein at sites ...
متن کاملThe risk of venous and arterial thrombosis in hyperhomocysteinemic subjects may be a result of elevated factor VIII levels.
In a large retrospective study of thrombophilic families, we analyzed 405 relatives of patients, hypothesizing that hyperhomocysteinemia and elevated factor VIII levels are closely related. Median factor VIII levels in hyperhomocysteinemic relatives were 169 IU/dL, compared with 136 IU/dL in normohomocysteinemic relatives (p =0.007), and were more often elevated (>150 IU/dL; p =0.006). Hyperhom...
متن کاملElevated factor VIII: an unfamiliar risk factor for cerebral venous thrombosis.
An elevated factor VIII level has been shown to be an independent risk factor for venous thrombosis. However, physicians screen for this factor far less frequently than they screen for other coagulopathies. The causes of increased factor VIII levels are likely a combination of genetic and acquired variables. The authors describe a case of a healthy 48-year-old woman found to have a cerebral ven...
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ژورنال
عنوان ژورنال: Pathophysiology of Haemostasis and Thrombosis
سال: 2003
ISSN: 1424-8832,1424-8840
DOI: 10.1159/000083835